Original article Biopharmaceuticals and Monoclonal Antibodies
Electrospun Fibers with Lactobacillus Acidophilus: A Poten- tial In Vitro Solution Against Gardnerella Infections

Fatima khilonawala; Amjaad Majeed Ali; Mustafa R. AL-Shaheen

Volume 1, Issue 1 , June 2023, Pages 1-11

  Bacterial vaginosis (BV) is a prevalent condition, impacting a third of women globally. It’s marked by reduced healthy lactobacilli and increased growth of certain anaerobes like Gardnerella. Even though antibiotics can be taken orally or applied vaginally to treat BV, about 50% of the patients ...  Read More

Original article Nanotechnology in Drug Delivery
Optimizing Chrysin’s Anticancer Efficacy on MDA-MB-231 Cells: Synthesis and Characterization of Chrysin-Loaded Gold/Chitosan Nanoparticles

Saja Hussain Dilfy; Nawras Najah mubark; Abiya Ahad Ahad

Volume 1, Issue 1 , June 2023, Pages 12-18

  This study showcases the creation of nanostructures that carry Chrysin (Chr), using gold (AuNPs) nanoparticles encased in chitosan. The Au particles were derived by reducing AuCl4− with tripolyphosphate (TPP) andCS. These gold/chitosan nanoparticles (Au/CS NPs) were analyzed using UV-Vis spectroscopy. ...  Read More

Review article CRISPR-Cas9 in Drug Discovery
Extracellular Vesicles as Promising Vectors for CRISPR/Cas9 Delivery: Advantages, Challenges, and Clinical Implications

Nameera siraj; Saja Hussain Dilfy; Rafat Hamdi Abduljaleel

Volume 1, Issue 1 , June 2023, Pages 19-33

  The CRISPR/Cas system, with its capacity to modify DNA sequences and thus change cellular and organ traits, holds promise for gene study and therapeutic interventions. However, the absence of reliable and efficient delivery mechanisms curtails its clinical usage. Extracellular vesicles (EVs) present ...  Read More

Review article Nanotechnology in Drug Delivery
Nanocarriers and Beyond: Innovations in Overcoming Barriers for Effective CNS Drug Delivery

Shahad Q. Al-Hamadiny; Rasha ibrahim salman; Ali Mohammed Al-Rawe

Volume 1, Issue 1 , June 2023, Pages 34-47

  Although numerous medications have the potential to treat central nervous system (CNS) disorders, only a small number of these drugs have actually been used successfully. It is as a result of the blood–brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSF) preventing them from exerting ...  Read More

Review article Biosimilars
Biomimetic Cell Membrane Vehicles: Navigating the Blood- Brain Barrier for Enhanced CNS Drug Delivery

Anmar Kamil Alalwani; Seema Ahad; Nedhal Hameed Sajet Dhaher

Volume 1, Issue 1 , June 2023, Pages 48-63

  Disorders of the CNS, such as brain tumors, ischemic strokes, Alzheimer’s, and Parkinson’s disease, pose a significant risk to human well-being. The presence of the BBB further complicates the transportation of medications and the development of targeted drug delivery methods. In recent decades, ...  Read More