Trends in Pharmaceutical Biotechnology (TPB) is a global scientific and open-access journal. It was established in 2023 by N A. Foundation Press and publishes Four issues annually. The journal accepts original, review articles and case reports. They are publishing under a Creative Commons Attribution 4.0 International (CC-BY) license. All the manuscripts are Double-blind peer-reviewed for scientific quality and acceptance.

 

Trends in Pharmaceutical Biotechnology(TPB) is a medium for global academics to exchange and disseminate their knowledge and the latest discoveries and advances. Trends in Pharmaceutical Biotechnology(TPB)  follows a libre open access policy under the Creative Commons Attribution 4.0 International public license. Submitted manuscripts are peer-reviewed by the Editorial Board and reviewers of Trends in Pharmaceutical Biotechnology (TPB)  before acceptance for publication.

 

Original article Immunotherapy
The Effect of FSH and Letrozole Treatment on The Lipid Profile in Women Being Treated for Fertility

Rana Kadhim Humaidan; Buthainah Al-Azzawi

Volume 2, Issue 1 , March 2024, Pages 1-10

Abstract
  Background: Letrozole, an aromatase inhibitor, affects the ovaries, breasts, adipose tissue, and bone by preventing androgen-to-estrogen conversion. This drastically reduces estrogen’s effects. Estrogens regulate fat metabolism by influencing lipid and lipoprotein metabolism. FSH stimulation, which ...  Read More

Original article Biosimilars
Antimicrobial Effects of Three Types of Metronidazole Drug on Salmonella enterica and Vibrio Fluvialis Isolated from Thi-Qar Province

Zaman K. Kareem Hanan; Ezat H. Mezal; Shatha B. Moussa; Adnan Abed Azeez; Hayder Fadhil Okab; Abdullah F. Yousif; Aliaa Kareem Hanan

Volume 2, Issue 1 , March 2024, Pages 11-16

Abstract
  The study examined the effect of Metronidazole on Salmonella enterica and vibrio fluvialis isolates, the test was carried out by using Metronidazole from three companies (a French company, Iraqi, and Egyptian), the two isolates were taken from diarrheal patients, some were resistant, others were sensitive ...  Read More

Original article Biosimilars
Biochemical Application of New Synthetic Compounds of Pyridine Derivatives Incorporating on Tetrazole Moieties

Noor Abdulhassan Alsaady; Anfal Abdulhassan Alsaady; Hawraa Abdul kazem Almajidi; zainab A.abid Alreda; Zahraa Ali Mohammed

Volume 2, Issue 1 , March 2024, Pages 17-23

Abstract
  Introduction: Pyridine has a liquid state, bad odor, pungent taste, toxic effects, and has the ability to mix with alcohol, water and some sperms, and it has many effects in the event of severe exposure such as suffocation. Methods: In this work, a new series of tetrazole derivatives is synthesized by ...  Read More

Biopharmaceuticals and Monoclonal Antibodies
Electrospun Fibers with Lactobacillus Acidophilus: A Poten- tial In Vitro Solution Against Gardnerella Infections

Fatima khilonawala; Amjaad Majeed Ali; Mustafa R. AL-Shaheen

Volume 1, Issue 1 , June 2023, , Pages 1-11

Abstract
  Bacterial vaginosis (BV) is a prevalent condition, impacting a third of women globally. It’s marked by reduced healthy lactobacilli and increased growth of certain anaerobes like Gardnerella. Even though antibiotics can be taken orally or applied vaginally to treat BV, about 50% of the patients ...  Read More

Nanotechnology in Drug Delivery
Optimizing Chrysin’s Anticancer Efficacy on MDA-MB-231 Cells: Synthesis and Characterization of Chrysin-Loaded Gold/Chitosan Nanoparticles

Saja Hussain Dilfy; Nawras Najah mubark; Abiya Ahad Ahad

Volume 1, Issue 1 , June 2023, , Pages 12-18

Abstract
  This study showcases the creation of nanostructures that carry Chrysin (Chr), using gold (AuNPs) nanoparticles encased in chitosan. The Au particles were derived by reducing AuCl4− with tripolyphosphate (TPP) andCS. These gold/chitosan nanoparticles (Au/CS NPs) were analyzed using UV-Vis spectroscopy. ...  Read More

CRISPR-Cas9 in Drug Discovery
Extracellular Vesicles as Promising Vectors for CRISPR/Cas9 Delivery: Advantages, Challenges, and Clinical Implications

Nameera siraj; Saja Hussain Dilfy; Rafat Hamdi Abduljaleel

Volume 1, Issue 1 , June 2023, , Pages 19-33

Abstract
  The CRISPR/Cas system, with its capacity to modify DNA sequences and thus change cellular and organ traits, holds promise for gene study and therapeutic interventions. However, the absence of reliable and efficient delivery mechanisms curtails its clinical usage. Extracellular vesicles (EVs) present ...  Read More

Biosimilars
Biomimetic Cell Membrane Vehicles: Navigating the Blood- Brain Barrier for Enhanced CNS Drug Delivery

Anmar Kamil Alalwani; Seema Ahad; Nedhal Hameed Sajet Dhaher

Volume 1, Issue 1 , June 2023, , Pages 48-63

Abstract
  Disorders of the CNS, such as brain tumors, ischemic strokes, Alzheimer’s, and Parkinson’s disease, pose a significant risk to human well-being. The presence of the BBB further complicates the transportation of medications and the development of targeted drug delivery methods. In recent decades, ...  Read More

Nanotechnology in Drug Delivery
Nanocarriers and Beyond: Innovations in Overcoming Barriers for Effective CNS Drug Delivery

Shahad Q. Al-Hamadiny; Rasha ibrahim salman; Ali Mohammed Al-Rawe

Volume 1, Issue 1 , June 2023, , Pages 34-47

Abstract
  Although numerous medications have the potential to treat central nervous system (CNS) disorders, only a small number of these drugs have actually been used successfully. It is as a result of the blood–brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSF) preventing them from exerting ...  Read More

Publisher:
N A. Foundation Press

Editor-in-Chief:
Ass.Prof.Dr. Younes Pilehvar

Associate Editor-in-Chief:
Prof Dr. Nosratollah Zarghami


Frequency: Quarterly

Print ISSN: 3005-7736

Online ISSN: 3005-7744

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